Endosomal Escape: Amphiphilic Polyelectrolyte Graft Copolymers Enhance the Activity of Cyclic Dinucleotide STING Agonists (Adv. Healthcare Mater. 2/2021)
نویسندگان
چکیده
Endosomal escape is a rate limiting step for many promising therapeutics, including cyclic dinucleotide (CDN) agonists of the stimulator interferon genes (STING) pathway. In article number 2001056, John T. Wilson and co-workers synthesize screen novel library polymers with pH-responsive, membrane-destabilizing activity evaluate their capacity to enhance cytosolic delivery CDNs, resulting in identification new drug carrier technologies potent STING activation.
منابع مشابه
Modified STING-activating cyclic dinucleotide derivatives significantly enhance the anti-tumor activity of therapeutic vaccines
The STING signaling pathway has emerged as a central TLR-independent mediator of host innate defense in response to sensing cytosolic nucleic acids, either through direct binding of CDNs secreted by intracellular bacteria, or through binding of a structurally distinct CDN produced by a host cell receptor, cyclic GMPAMP (cGAMP) synthase (cGAS), in response to binding cytosolic double-stranded DN...
متن کاملClickable Amphiphilic Triblock Copolymers.
Amphiphilic polymers have recently garnered much attention due to their potential use in drug-delivery and other biomedical applications. A modular synthesis of these polymers is extremely desirable since it offers precise individual block characterization and increased yields. We present here for the first time a modular synthesis of poly(oxazoline)-poly(siloxane)-poly(oxazoline) block copolym...
متن کاملNon-Surface Activity of Cationic Amphiphilic Diblock Copolymers
Cationic amphiphilic diblock copolymers containing quaternized poly (2vinylpyridine) chain as a hydrophilic segment (PIp-b-PNMe2VP) were synthesized by living anionic polymerization. By IR measurement, we confirmed the quaternization of the polymer (PIp-b-PNMe2VP), and determined the degree of quaternization by conductometric titration. The surface tension experiment showed that the polymers ar...
متن کاملAmphiphilic block copolymers enhance the cellular uptake of DNA molecules through a facilitated plasma membrane transport
Amphiphilic block copolymers have been developed recently for their efficient, in vivo transfection activities in various tissues. Surprisingly, we observed that amphiphilic block copolymers such as Lutrol® do not allow the transfection of cultured cells in vitro, suggesting that the cell environment is strongly involved in their mechanism of action. In an in vitro model mimicking the in vivo s...
متن کاملMetamaterials: Snapping Mechanical Metamaterials under Tension (Adv. Mater. 39/2015).
By exploiting snap-through instabilities, D. Pasini and co-workers design a damage-tolerant mechanical metamaterial that snaps sequentially under tension, thereby accommodating a very large deformation up to 150%. On page 5931, they describe how the nonlinear mechanical response of the metamaterial can be robustly programmed by tuning the architecture of its unit cell.
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Advanced Healthcare Materials
سال: 2021
ISSN: ['2192-2640', '2192-2659']
DOI: https://doi.org/10.1002/adhm.202170004